Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis

Wiskott-Aldrich syndrome protein (WASp) is essential for optimal T cell activation. Patients with WAS exhibit both immunodeficiency and a marked susceptibility to systemic autoimmunity. We investigated whether alterations in Treg function might explain these paradoxical observations. While WASp-defi...

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Bibliografiske detaljer
Main Authors: Humblet-Baron, Stephanie, Sather, Blythe, Anover, Stephanie, Becker-Herman, Shirly, Kasprowicz, Debora J., Khim, Socheath, Nguyen, Thuc, Hudkins-Loya, Kelly, Alpers, Charles E., Ziegler, Steve F., Ochs, Hans, Torgerson, Troy, Campbell, Daniel J., Rawlings, David J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1764857/
https://ncbi.nlm.nih.gov/pubmed/17218989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29539
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