B cell-intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome

Patients with Wiskott-Aldrich syndrome (WAS) exhibit prominent defects in splenic marginal zone (MZ), resulting in abnormal T-cell-independent antibody responses and increased bacterial infections. B-cell-intrinsic deletion of the affected gene WAS protein (WASp) markedly reduces splenic MZ B cells,...

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Udgivet i:Eur J Immunol
Main Authors: Kolhatkar, Nikita S., Scharping, Nicole E., Sullivan, Jenna M., Jacobs, Holly M., Schwartz, Marc A., Khim, Socheath, Notarangelo, Luigi D., Thrasher, Adrian J., Rawlings, David J., Jackson, Shaun W.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679197/
https://ncbi.nlm.nih.gov/pubmed/26256668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545644
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