Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

BACKGROUND. Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients with pancreatic cancer and analyzed pharmacodyna...

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Hlavní autoři: Wolpin, Brian M., Rubinson, Douglas A., Wang, Xiaoxu, Chan, Jennifer A., Cleary, James M., Enzinger, Peter C., Fuchs, Charles S., McCleary, Nadine J., Meyerhardt, Jeffrey A., Ng, Kimmie, Schrag, Deborah, Sikora, Allison L., Spicer, Beverly A., Killion, Leah, Mamon, Harvey, Kimmelman, Alec C.
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2014
Témata:
Clinical Trial Results
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041680/
https://ncbi.nlm.nih.gov/pubmed/24821822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2014-0086
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