Pharmacokinetics and pharmacodynamics of hydroxychloroquine in hospitalized patients with COVID-19

BACKGROUND: Hydroxychloroquine (HCQ) dosage required to reach circulating levels that inhibit SARS-Cov-2 are extrapolated from pharmacokinetic data in non-COVID-19 patients. METHODS: We performed a population-pharmacokinetic analysis from 104 consecutive COVID-19 hospitalized patients (31 in intensi...

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Detalhes bibliográficos
Publicado no:Therapie
Main Authors: Zahr, Noël, Urien, Saik, Llopis, Benoit, Pourcher, Valérie, Paccoud, Olivier, Bleibtreu, Alexandre, Mayaux, Julien, Gandjbakhch, Estelle, Hekimian, Guillaume, Combes, Alain, Benveniste, Olivier, Saadoun, David, Allenbach, Yves, Pinna, Bruno, Cacoub, Patrice, Funck-Brentano, Christian, Salem, Joe-Elie
Formato: Artigo
Idioma:Inglês
Publicado em: Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. 2021
Assuntos:
Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7842207/
https://ncbi.nlm.nih.gov/pubmed/33558079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.therap.2021.01.056
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