Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

BACKGROUND. Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients with pancreatic cancer and analyzed pharmacodyna...

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Main Authors: Wolpin, Brian M., Rubinson, Douglas A., Wang, Xiaoxu, Chan, Jennifer A., Cleary, James M., Enzinger, Peter C., Fuchs, Charles S., McCleary, Nadine J., Meyerhardt, Jeffrey A., Ng, Kimmie, Schrag, Deborah, Sikora, Allison L., Spicer, Beverly A., Killion, Leah, Mamon, Harvey, Kimmelman, Alec C.
Format: Artigo
Jezik:Inglês
Izdano: AlphaMed Press 2014
Teme:
Clinical Trial Results
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041680/
https://ncbi.nlm.nih.gov/pubmed/24821822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2014-0086
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