Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

BACKGROUND. Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients with pancreatic cancer and analyzed pharmacodyna...

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Detalhes bibliográficos
Main Authors: Wolpin, Brian M., Rubinson, Douglas A., Wang, Xiaoxu, Chan, Jennifer A., Cleary, James M., Enzinger, Peter C., Fuchs, Charles S., McCleary, Nadine J., Meyerhardt, Jeffrey A., Ng, Kimmie, Schrag, Deborah, Sikora, Allison L., Spicer, Beverly A., Killion, Leah, Mamon, Harvey, Kimmelman, Alec C.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2014
Assuntos:
Clinical Trial Results
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041680/
https://ncbi.nlm.nih.gov/pubmed/24821822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2014-0086
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