Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

Myotonic dystrophy type 1 (DM1) is a dominantly inherited neuromuscular disorder resulting from expression of RNA containing an expanded CUG repeat (CUG(exp)). The pathogenic RNA is retained in nuclear foci. Poly-(CUG) binding proteins in the Muscleblind-like (MBNL) family are sequestered in foci, c...

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Detalhes bibliográficos
Main Authors: Hoskins, Jason W., Ofori, Leslie O., Chen, Catherine Z., Kumar, Amit, Sobczak, Krzysztof, Nakamori, Masayuki, Southall, Noel, Patnaik, Samarjit, Marugan, Juan J., Zheng, Wei, Austin, Christopher P., Disney, Matthew D., Miller, Benjamin L., Thornton, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041448/
https://ncbi.nlm.nih.gov/pubmed/24799433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku275
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