The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage

Mus81-Mms4/EME1 is a DNA structure-selective endonuclease that cleaves joint DNA molecules that form during homologous recombination in mitotic and meiotic cells. Here, we demonstrate by kinetic analysis using physically tethered DNA substrates that budding yeast Mus81-Mms4 requires inherent rotatio...

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Hlavní autoři: Mukherjee, Sucheta, Wright, William Douglass, Ehmsen, Kirk Tevebaugh, Heyer, Wolf-Dietrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041439/
https://ncbi.nlm.nih.gov/pubmed/24744239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku265
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