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A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4

The DNA structure-selective endonuclease Mus81-Mms4/Eme1 incises a number of nicked joint molecule substrates in vitro. 3′-flaps are an excellent in vitro substrate for Mus81-Mms4/Eme1. Mutants in MUS81 are synthetically lethal with mutations in the 5′-flap endonuclease FEN1/Rad27 in Saccharomyces c...

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Hlavní autoři: Ehmsen, Kirk Tevebaugh, Heyer, Wolf-Dietrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665226/
https://ncbi.nlm.nih.gov/pubmed/19211663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp038
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