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Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex

MUS81 shares a high-degree homology with the catalytic XPF subunit of the XPF–ERCC1 endonuclease complex. It is catalytically active only when complexed with the regulatory subunits Mms4 or Eme1 in budding and fission yeasts, respectively, and EME1 or EME2 in humans. Although Mus81 complexes are imp...

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Detalhes bibliográficos
Main Authors: Amangyeld, Tamir, Shin, Yong-Keol, Lee, Miju, Kwon, Buki, Seo, Yeon-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027171/
https://ncbi.nlm.nih.gov/pubmed/24692662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku237
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