Engineered zinc-finger transcription factors activate OCT4 (POU5F1), SOX2, KLF4, c-MYC (MYC) and miR302/367

Artificial transcription factors are powerful tools for regulating gene expression. Here we report results with engineered zinc-finger transcription factors (ZF-TFs) targeting four protein-coding genes, OCT4, SOX2, KLF4 and c-MYC, and one noncoding ribonucleic acid (RNA) gene, the microRNA (miRNA) m...

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Autors principals: Ji, Qingzhou, Fischer, Ashley L., Brown, Clyde R., Eastlund, Erik R., Dvash, Tamar, Zhong, Bonan, Gerber, Mark A., Lyons, Ian, Knight, Scott W., Kreader, Carol A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041418/
https://ncbi.nlm.nih.gov/pubmed/24792165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku243
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