Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

OBJECTIVES: Rheumatoid Arthritis (RA) is a chronic inflammatory disease of unclear aetiology, which is associated with inflamed human fibroblast-like synoviocytes (HFLS). Epidemiological studies have identified a positive correlation between tobacco smoking (a rich source of aryl hydrocarbon recepto...

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Main Authors: Lahoti, Tejas S, John, Kaarthik, Hughes, Jarod M, Kusnadi, Ann, Murray, Iain A, Krishnegowda, Gowdahalli, Amin, Shantu, Perdew, Gary H
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041386/
https://ncbi.nlm.nih.gov/pubmed/23349129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-202639
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