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Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins

Killer lymphocyte granzyme (Gzm) serine proteases induce apoptosis of pathogen-infected cells and tumor cells. Many known Gzm substrates are nucleic acid binding proteins, and the Gzms accumulate in the target cell nucleus by an unknown mechanism. Here we show that human Gzms bind to DNA and RNA wit...

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Sonraí Bibleagrafaíochta
Main Authors: Thomas, Marshall P., Whangbo, Jennifer, McCrossan, Geoffrey, Deutsch, Aaron, Martinod, Kimberly, Walch, Michael, Lieberman, Judy
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041364/
https://ncbi.nlm.nih.gov/pubmed/24771851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303296
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