Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins

Killer lymphocyte granzyme (Gzm) serine proteases induce apoptosis of pathogen-infected cells and tumor cells. Many known Gzm substrates are nucleic acid binding proteins, and the Gzms accumulate in the target cell nucleus by an unknown mechanism. Here we show that human Gzms bind to DNA and RNA wit...

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Bibliographic Details
Main Authors: Thomas, Marshall P., Whangbo, Jennifer, McCrossan, Geoffrey, Deutsch, Aaron, Martinod, Kimberly, Walch, Michael, Lieberman, Judy
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041364/
https://ncbi.nlm.nih.gov/pubmed/24771851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303296
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