Cathepsin S is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR(2)-dependent Mechanism in Mice

BACKGROUND & AIMS: Although proteases control inflammation and pain, the identity, cellular origin, mechanism of action, and causative role of proteases that are activated during disease are not defined. We investigated the activation and function of cysteine cathepsins (Cat) in colitis. METHODS...

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Main Authors: Cattaruzza, Fiore, Lyo, Victoria, Jones, Ella, Pham, David, Hawkins, James, Kirkwood, Kimberley, Valdez-Morales, Eduardo, Ibeakanma, Charles, Vanner, Stephen J., Bogyo, Matthew, Bunnett, Nigel W.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041343/
https://ncbi.nlm.nih.gov/pubmed/21802389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.07.035
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