Uterine leiomyoma-linked MED12 mutations disrupt Mediator-associated CDK activity

Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of these mutations on Mediator function and the molecular basis for their tumorigenic potential remain unknown. To clarify the...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Turunen, Mikko, Spaeth, Jason M., Keskitalo, Salla, Park, Min Ju, Kivioja, Teemu, Clark, Alison D., Mäkinen, Netta, Gao, Fangjian, Palin, Kimmo, Nurkkala, Helka, Vähärautio, Anna, Aavikko, Mervi, Kämpjärvi, Kati, Vahteristo, Pia, Kim, Chongwoo A., Aaltonen, Lauri A., Varjosalo, Markku, Taipale, Jussi, Boyer, Thomas G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041330/
https://ncbi.nlm.nih.gov/pubmed/24746821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.047
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