11β-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

In aging humans and rodents, inter-individual differences in cognitive function have been ascribed to variations in long-term glucocorticoid exposure. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates the active glucocorticoid cortisol from circulating inert cortisone, thus amplifying i...

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Bibliografiske detaljer
Main Authors: Sandeep, Thekkepat C., Yau, Joyce L. W., MacLullich, Alasdair M. J., Noble, June, Deary, Ian J., Walker, Brian R., Seckl, Jonathan R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC404114/
https://ncbi.nlm.nih.gov/pubmed/15071189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306996101
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