Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/TNFSF10/Apo2L) holds promise for cancer therapy as it induces apoptosis in a large variety of cancer cells while exerting negligible toxicity in normal ones. However, TRAIL can also induce proliferative and migratory signaling in cancer...

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Главные авторы: Pavet, V, Shlyakhtina, Y, He, T, Ceschin, D G, Kohonen, P, Perälä, M, Kallioniemi, O, Gronemeyer, H
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040674/
https://ncbi.nlm.nih.gov/pubmed/24481457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.5
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