Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma

Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm with transient response to conventional chemotherapy. We here investigated the role of the Bcl-2 homology domain 3-only protein NOXA for life–death decision in MCL. Surprisingly, NOXA (PMAIP1) mRNA and NOXA protein levels were extremely d...

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Autors principals: Dengler, M A, Weilbacher, A, Gutekunst, M, Staiger, A M, Vöhringer, M C, Horn, H, Ott, G, Aulitzky, W E, van der Kuip, H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040662/
https://ncbi.nlm.nih.gov/pubmed/24457957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.552
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