Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

BACKGROUND: Mantle cell lymphoma (MCL) is an aggressive B-non-Hodgkin lymphoma with generally poor outcome. MCL is characterized by an aberrantly high cyclin D1-driven CDK4 activity. New molecular targeted therapies such as inhibitors of the ubiquitin-proteasome system (UPS) have shown promising res...

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Udgivet i:J Hematol Oncol
Main Authors: Heine, Simon, Kleih, Markus, Giménez, Neus, Böpple, Kathrin, Ott, German, Colomer, Dolors, Aulitzky, Walter E., van der Kuip, Heiko, Silkenstedt, Elisabeth
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123978/
https://ncbi.nlm.nih.gov/pubmed/30180865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0657-6
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