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Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver

Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids. Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes encoding enzymes of fatty aci...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Dobrzyn, Pawel, Dobrzyn, Agnieszka, Miyazaki, Makoto, Cohen, Paul, Asilmaz, Esra, Hardie, D. Grahame, Friedman, Jeffrey M., Ntambi, James M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404058/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15096593/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401627101
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