CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer

Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are poorly understood. The DNA binding protein CTCF regulates a diverse array of epigenetic processes and is frequently altered by hemizygous deletio...

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Main Authors: Kemp, Christopher J., Moore, James M., Moser, Russell, Bernard, Brady, Teater, Matt, Smith, Leslie E., Rabaia, Natalia, Gurley, Kay E., Guinney, Justin, Busch, Stephanie E., Shaknovich, Rita, Lobanenkov, Victor V., Liggitt, Denny, Shmulevich, Ilya, Melnick, Ari, Filippova, Galina N.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040130/
https://ncbi.nlm.nih.gov/pubmed/24794443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.004
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