Smg1 haploinsufficiency predisposes to tumor formation and inflammation

SMG1 is a member of the phosphoinositide kinase-like kinase family of proteins that includes ATM, ATR, and DNA-PK, proteins with known roles in DNA damage and cellular stress responses. SMG1 has a well-characterized role in nonsense-mediated decay as well as suggested roles in the DNA damage respons...

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Autores principales: Roberts, Tara L., Ho, Uda, Luff, John, Lee, C. Soon, Apte, Simon H., MacDonald, Kelli P. A., Raggat, Liza J., Pettit, Allison R., Morrow, Carl A., Waters, Michael J., Chen, Phil, Woods, Rick G., Thomas, Gethin P., St. Pierre, Liam, Farah, Camile S., Clarke, Raymond A., Brown, James A. L., Lavin, Martin F.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557096/
https://ncbi.nlm.nih.gov/pubmed/23277562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215696110
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