Smg1 haploinsufficiency predisposes to tumor formation and inflammation

SMG1 is a member of the phosphoinositide kinase-like kinase family of proteins that includes ATM, ATR, and DNA-PK, proteins with known roles in DNA damage and cellular stress responses. SMG1 has a well-characterized role in nonsense-mediated decay as well as suggested roles in the DNA damage respons...

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Bibliografiske detaljer
Main Authors: Roberts, Tara L., Ho, Uda, Luff, John, Lee, C. Soon, Apte, Simon H., MacDonald, Kelli P. A., Raggat, Liza J., Pettit, Allison R., Morrow, Carl A., Waters, Michael J., Chen, Phil, Woods, Rick G., Thomas, Gethin P., St. Pierre, Liam, Farah, Camile S., Clarke, Raymond A., Brown, James A. L., Lavin, Martin F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557096/
https://ncbi.nlm.nih.gov/pubmed/23277562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215696110
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