CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer

Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are poorly understood. The DNA binding protein CTCF regulates a diverse array of epigenetic processes and is frequently altered by hemizygous deletio...

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Библиографические подробности
Главные авторы: Kemp, Christopher J., Moore, James M., Moser, Russell, Bernard, Brady, Teater, Matt, Smith, Leslie E., Rabaia, Natalia, Gurley, Kay E., Guinney, Justin, Busch, Stephanie E., Shaknovich, Rita, Lobanenkov, Victor V., Liggitt, Denny, Shmulevich, Ilya, Melnick, Ari, Filippova, Galina N.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040130/
https://ncbi.nlm.nih.gov/pubmed/24794443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.004
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