CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer

Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are poorly understood. The DNA binding protein CTCF regulates a diverse array of epigenetic processes and is frequently altered by hemizygous deletio...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Kemp, Christopher J., Moore, James M., Moser, Russell, Bernard, Brady, Teater, Matt, Smith, Leslie E., Rabaia, Natalia, Gurley, Kay E., Guinney, Justin, Busch, Stephanie E., Shaknovich, Rita, Lobanenkov, Victor V., Liggitt, Denny, Shmulevich, Ilya, Melnick, Ari, Filippova, Galina N.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040130/
https://ncbi.nlm.nih.gov/pubmed/24794443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.004
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