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Decorin differentially modulates the activity of insulin receptor isoform A ligands

The proteoglycan decorin, a key component of the tumor stroma, regulates the action of several tyrosine-kinase receptors, including the EGFR, Met and the IGF-IR. Notably, the action of decorin in regulating the IGF-I system differs between normal and transformed cells. In normal cells, decorin binds...

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Hlavní autoři: Morcavallo, Alaide, Buraschi, Simone, Xu, Shi-Qiong, Belfiore, Antonino, Schaefer, Liliana, Iozzo, Renato V., Morrione, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039619/
https://ncbi.nlm.nih.gov/pubmed/24389353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2013.12.010
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