Human Neural Stem Cells Survive Long Term in the Midbrain of Dopamine-Depleted Monkeys After GDNF Overexpression and Project Neurites Toward an Appropriate Target

Transplanted multipotent human fetal neural stem cells (hfNSCs) significantly improved the function of parkinsonian monkeys in a prior study primarily by neuroprotection, with only 3%–5% of cells expressing a dopamine (DA) phenotype. In this paper, we sought to determine whether further manipulation...

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Hlavní autoři: Wakeman, Dustin R., Redmond, D. Eugene, Dodiya, Hemraj B., Sladek, John R., Leranth, Csaba, Teng, Yang D., Samulski, R. Jude, Snyder, Evan Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2014
Témata:
Fetal and Neonatal Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039459/
https://ncbi.nlm.nih.gov/pubmed/24744393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2013-0208
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