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AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons

Neural transplantation offers the potential of treating Parkinson’s disease by grafting fetal dopamine neurons to depleted regions of the brain. However, clinical studies of neural grafting in Parkinson’s disease have produced only modest improvements. One of the main reasons for this is the low sur...

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Autors principals: Elsworth, JD, Redmond, DE, Leranth, C, Bjugstad, KB, Sladek, JR, Collier, TJ, Foti, SB, Samulski, RJ, Vives, KP, Roth, RH
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855210/
https://ncbi.nlm.nih.gov/pubmed/18346734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2008.01.026
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