Comparison of Fetal Mesencephalic Grafts, AAV-delivered GDNF, and Both Combined in an MPTP-induced Nonhuman Primate Parkinson's Model

We combined viral vector delivery of human glial-derived neurotrophic factor (GDNF) with the grafting of dopamine (DA) precursor cells from fetal ventral mesencephalon (VM) to determine whether these strategies would improve the anti-Parkinson's effects in 1-methyl-4-phenyl-1,2,3,6-tetrahydropy...

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Detalhes bibliográficos
Main Authors: Redmond Jr, D Eugene, McEntire, Caleb R S, Kingsbery, Joseph P, Leranth, Csaba, Elsworth, John D, Bjugstad, Kimberly B, Roth, Robert H, Samulski, Richard J, Sladek Jr, John R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863793/
https://ncbi.nlm.nih.gov/pubmed/23913185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.180
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