MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

While MDM2 inhibitors hold great promise as cancer therapeutics, drug resistance will likely limit their efficacy as single agents. To identify drug combinations that might circumvent resistance, we screened for agents that could synergize with MDM2 inhibition in the suppression of cell viability. W...

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Detalhes bibliográficos
Main Authors: Saiki, Anne Y., Caenepeel, Sean, Yu, Dongyin, Lofgren, Julie A., Osgood, Tao, Robertson, Rebecca, Canon, Jude, Su, Cheng, Jones, Adrie, Zhao, Xiaoning, Deshpande, Chetan, Payton, Marc, Ledell, Jebediah, Hughes, Paul E., Oliner, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039142/
https://ncbi.nlm.nih.gov/pubmed/24810962
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