Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2–p53 Interaction

[Image: see text] Continued optimization of the N-substituent in the piperidinone series provided potent piperidinone–pyridine inhibitors 6, 7, 14, and 15 with improved pharmacokinetic properties in rats. Reducing structure complexity of the N-alkyl substituent led to the discovery of 23, a potent a...

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Detalhes bibliográficos
Main Authors: Yu, Ming, Wang, Yingcai, Zhu, Jiang, Bartberger, Michael D., Canon, Jude, Chen, Ada, Chow, David, Eksterowicz, John, Fox, Brian, Fu, Jiasheng, Gribble, Michael, Huang, Xin, Li, Zhihong, Liu, Jiwen (Jim), Lo, Mei-chu, McMinn, Dustin, Oliner, Jonathan D., Osgood, Tao, Rew, Yosup, Saiki, Anne Y., Shaffer, Paul, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H., Medina, Julio C., Sun, Daqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137378/
https://ncbi.nlm.nih.gov/pubmed/25147610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500142b
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