Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

ER aminopeptidase 1 (ERAP1) customizes antigenic peptide precursors for MHC class I presentation and edits the antigenic peptide repertoire. Coding single nucleotide polymorphisms (SNPs) in ERAP1 were recently linked with predisposition to autoimmune disease, suggesting a link between pathogenesis o...

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Bibliografiset tiedot
Päätekijät: Evnouchidou, Irini, Kamal, Ram P., Seregin, Sergey S., Goto, Yoshikuni, Tsujimoto, Masafumi, Hattori, Akira, Voulgari, Paraskevi V., Drosos, Alexandros A., Amalfitano, Andrea, York, Ian A., Stratikos, Efstratios
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039038/
https://ncbi.nlm.nih.gov/pubmed/21242517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003337
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