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Basal body proteins regulate Notch signaling through endosomal trafficking

Proteins associated with primary cilia and basal bodies mediate numerous signaling pathways, but little is known about their role in Notch signaling. Here, we report that loss of the Bardet-Biedl syndrome proteins BBS1 or BBS4 produces increased Notch-directed transcription in a zebrafish reporter l...

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Detalhes bibliográficos
Main Authors: Leitch, Carmen C., Lodh, Sukanya, Prieto-Echagüe, Victoria, Badano, Jose L., Zaghloul, Norann A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038940/
https://ncbi.nlm.nih.gov/pubmed/24681783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.130344
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