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The vacuolar proton pump (V-ATPase) is required for Notch signaling and endosomal trafficking in Drosophila

We have identified Rabconnectin-3 alpha and beta (Rbcn-3A and B) as two regulators of Notch signaling in Drosophila. We found that, in addition to disrupting Notch signaling, mutations in Rbcn-3A and B cause defects in endocytic trafficking, where Notch and other membrane proteins accumulate in late...

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Détails bibliographiques
Auteurs principaux: Yan, Yan, Denef, Natalie, Schüpbach, Trudi
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758249/
https://ncbi.nlm.nih.gov/pubmed/19758563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.07.001
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