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The vacuolar proton pump (V-ATPase) is required for Notch signaling and endosomal trafficking in Drosophila
We have identified Rabconnectin-3 alpha and beta (Rbcn-3A and B) as two regulators of Notch signaling in Drosophila. We found that, in addition to disrupting Notch signaling, mutations in Rbcn-3A and B cause defects in endocytic trafficking, where Notch and other membrane proteins accumulate in late...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758249/ https://ncbi.nlm.nih.gov/pubmed/19758563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.07.001 |
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