Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.

The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal arrangements in its 5' noncoding region in approximately 30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor typ...

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Autors principals: Migliazza, A, Martinotti, S, Chen, W, Fusco, C, Ye, B H, Knowles, D M, Offit, K, Chaganti, R S, Dalla-Favera, R
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC40389/
https://ncbi.nlm.nih.gov/pubmed/8618933
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