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Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease

Human naive and germinal center (GC) B cells were sorted by flow cytometry and rearranged V(H) region genes were amplified and sequenced from single cells. Whereas no deletions or insertions were found in naive B cells, ≈4% of in-frame and >40% of out-of-frame rearrangements of GC B cells harbore...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Goossens, Tina, Klein, Ulf, Küppers, Ralf
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The National Academy of Sciences 1998
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC19376/
https://ncbi.nlm.nih.gov/pubmed/9482908
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