Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
Human naive and germinal center (GC) B cells were sorted by flow cytometry and rearranged V(H) region genes were amplified and sequenced from single cells. Whereas no deletions or insertions were found in naive B cells, ≈4% of in-frame and >40% of out-of-frame rearrangements of GC B cells harbored d...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1998
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9482908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.5.2463 |
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