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Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.

The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal arrangements in its 5' noncoding region in approximately 30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Migliazza, A, Martinotti, S, Chen, W, Fusco, C, Ye, B H, Knowles, D M, Offit, K, Chaganti, R S, Dalla-Favera, R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40389/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8618933/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.26.12520
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