Type I IFN signaling in CD8(–) DCs impairs Th1-dependent malaria immunity

Many pathogens, including viruses, bacteria, and protozoan parasites, suppress cellular immune responses through activation of type I IFN signaling. Recent evidence suggests that immune suppression and susceptibility to the malaria parasite, Plasmodium, is mediated by type I IFN; however, it is uncl...

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Detalhes bibliográficos
Main Authors: Haque, Ashraful, Best, Shannon E., Montes de Oca, Marcela, James, Kylie R., Ammerdorffer, Anne, Edwards, Chelsea L., de Labastida Rivera, Fabian, Amante, Fiona H., Bunn, Patrick T., Sheel, Meru, Sebina, Ismail, Koyama, Motoko, Varelias, Antiopi, Hertzog, Paul J., Kalinke, Ulrich, Gun, Sin Yee, Rénia, Laurent, Ruedl, Christiane, MacDonald, Kelli P.A., Hill, Geoffrey R., Engwerda, Christian R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038565/
https://ncbi.nlm.nih.gov/pubmed/24789914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70698
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