In vitro supplementation with deoxynucleoside monophosphates rescues mitochondrial DNA depletion

Mitochondrial DNA depletion syndromes are a genetically heterogeneous group of often severe diseases, characterized by reduced cellular mitochondrial DNA content. Investigation of potential therapeutic strategies for mitochondrial DNA depletion syndromes will be dependent on good model systems. We h...

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Détails bibliographiques
Auteurs principaux: Bulst, Stefanie, Holinski-Feder, Elke, Payne, Brendan, Abicht, Angela, Krause, Sabine, Lochmüller, Hanns, Chinnery, Patrick F., Walter, Maggie C., Horvath, Rita
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038513/
https://ncbi.nlm.nih.gov/pubmed/22608879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2012.04.022
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