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In vitro supplementation with deoxynucleoside monophosphates rescues mitochondrial DNA depletion

Mitochondrial DNA depletion syndromes are a genetically heterogeneous group of often severe diseases, characterized by reduced cellular mitochondrial DNA content. Investigation of potential therapeutic strategies for mitochondrial DNA depletion syndromes will be dependent on good model systems. We h...

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Detalhes bibliográficos
Main Authors: Bulst, Stefanie, Holinski-Feder, Elke, Payne, Brendan, Abicht, Angela, Krause, Sabine, Lochmüller, Hanns, Chinnery, Patrick F., Walter, Maggie C., Horvath, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038513/
https://ncbi.nlm.nih.gov/pubmed/22608879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2012.04.022
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