Safety and Efficacy Assessment of Two New Leprosy Skin Test Antigens: Randomized Double Blind Clinical Study

BACKGROUND: New tools are required for the diagnosis of pre-symptomatic leprosy towards further reduction of disease burden and its associated reactions. To address this need, two new skin test antigens were developed to assess safety and efficacy in human trials. METHODS: A Phase I safety trial was...

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Main Authors: Rivoire, Becky L., Groathouse, Nathan A., TerLouw, Stephen, Neupane, Kapil Dev, Ranjit, Chaman, Sapkota, Bishwa Raj, Khadge, Saraswoti, Kunwar, Chatra B., Macdonald, Murdo, Hawksworth, Rachel, Thapa, Min B., Hagge, Deanna A., Tibbals, Melinda, Smith, Carol, Dube, Tina, She, Dewei, Wolff, Mark, Zhou, Eric, Makhene, Mamodikoe, Mason, Robin, Sizemore, Christine, Brennan, Patrick J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038488/
https://ncbi.nlm.nih.gov/pubmed/24874401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002811
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