SHP2 Regulates Chondrocyte Terminal Differentiation, Growth Plate Architecture and Skeletal Cell Fates

Loss of PTPN11/SHP2 in mice or in human metachondromatosis (MC) patients causes benign cartilage tumors on the bone surface (exostoses) and within bones (enchondromas). To elucidate the mechanisms underlying cartilage tumor formation, we investigated the role of SHP2 in the specification, maturation...

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Bibliographic Details
Main Authors: Bowen, Margot E., Ayturk, Ugur M., Kurek, Kyle C., Yang, Wentian, Warman, Matthew L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038465/
https://ncbi.nlm.nih.gov/pubmed/24875294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004364
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