Modeling Nikkomycin Z Dosing and Pharmacology in Murine Pulmonary Coccidioidomycosis Preparatory to Phase 2 Clinical Trials

Nikkomycin Z (NikZ) is a chitin synthase inhibitor with activity against Coccidioides species that is being developed as a first-in-class orphan product for treatment of coccidioidomycosis. It has previously been shown to reduce lethal respiratory infections in mice to undetectable levels when treat...

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Hlavní autoři: Shubitz, Lisa F., Trinh, Hien T., Perrill, Robert H., Thompson, C. Michael, Hanan, Nathan J., Galgiani, John N., Nix, David E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038145/
https://ncbi.nlm.nih.gov/pubmed/24421256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu029
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