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CYP3A5 Gene Variation Influences both Systemic and Intrarenal Tacrolimus Disposition
We evaluated the hypothesis that CYP3A5 expression can affect intrarenal tacrolimus accumulation. An oral dose of tacrolimus was administered to 24 healthy volunteers who were selected based on their CYP3A5 genotype. Compared to CYP3A5 nonexpressors, expressors had a 1.6-fold higher oral tacrolimus...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038024/ https://ncbi.nlm.nih.gov/pubmed/23073208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2012.175 |
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