CYP3A5 Gene Variation Influences Cyclosporine A Metabolite Formation and Renal Cyclosporine Disposition

BACKGROUND: Higher concentrations of AM19 and AM1c9, secondary metabolites of cyclosporine A (CsA), have been associated with nephrotoxicity in organ transplant patients. The risk of renal toxicity may depend upon the accumulation of CsA and its metabolites in the renal tissue. We evaluated the hypo...

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Detaylı Bibliyografya
Asıl Yazarlar: Zheng, Songmao, Tasnif, Yasar, Hebert, Mary F., Davis, Connie L., Shitara, Yoshihisa, Calamia, Justina C., Lin, Yvonne S., Shen, Danny D., Thummel, Kenneth E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604156/
https://ncbi.nlm.nih.gov/pubmed/23354298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e31827e6ad9
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