Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation

BACKGROUND: The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug metabolism via cytochrome P450 (CYP) 3A. The resulting low oral bioavailability can be boosted by co-administration of P-gp or CYP3A4 inhibitors. METH...

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Bibliographische Detailangaben
Hauptverfasser: Hendrikx, J J M A, Lagas, J S, Wagenaar, E, Rosing, H, Schellens, J H M, Beijnen, J H, Schinkel, A H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037831/
https://ncbi.nlm.nih.gov/pubmed/24781280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.222
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