Sorafenib Cardiotoxicity Increases Mortality after Myocardial Infarction

RATIONALE: Sorafenib is an effective treatment for renal cell carcinoma, but recent clinical reports have documented its cardiotoxicity through an unknown mechanism. OBJECTIVE: Determining the mechanism of sorafenib-mediated cardiotoxicity. METHODS AND RESULTS: Mice treated with sorafenib or vehicle...

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Main Authors:	Duran, Jason M., Makarewich, Catherine A., Trappanese, Danielle, Gross, Polina, Husain, Sharmeen, Dunn, Jonathan, Lal, Hind, Sharp, Thomas E., Starosta, Timothy, Vagnozzi, Ronald J., Berretta, Remus M., Barbe, Mary, Yu, Daohai, Gao, Erhe, Kubo, Hajime, Force, Thomas, Houser, Steven R
Format:	Artigo
Language:	Inglês
Published:	2014
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4037647/ https://ncbi.nlm.nih.gov/pubmed/24718482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.303200
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Sorafenib Cardiotoxicity Increases Mortality after Myocardial Infarction

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