Sorafenib Cardiotoxicity Increases Mortality after Myocardial Infarction

RATIONALE: Sorafenib is an effective treatment for renal cell carcinoma, but recent clinical reports have documented its cardiotoxicity through an unknown mechanism. OBJECTIVE: Determining the mechanism of sorafenib-mediated cardiotoxicity. METHODS AND RESULTS: Mice treated with sorafenib or vehicle...

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Hlavní autoři: Duran, Jason M., Makarewich, Catherine A., Trappanese, Danielle, Gross, Polina, Husain, Sharmeen, Dunn, Jonathan, Lal, Hind, Sharp, Thomas E., Starosta, Timothy, Vagnozzi, Ronald J., Berretta, Remus M., Barbe, Mary, Yu, Daohai, Gao, Erhe, Kubo, Hajime, Force, Thomas, Houser, Steven R
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037647/
https://ncbi.nlm.nih.gov/pubmed/24718482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.303200
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