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Calcineurin down-regulation in the amygdala is sufficient to induce anxiety-like and depression-like behaviors in C57BL/6J male mice

BACKGROUND: The calcium-dependent phosphatase calcineurin is highly expressed in the amygdala, a brain area important for behaviors related to mood disorders and anxiety. Organ transplant patients are administered the calcineurin inhibitor Cyclosporin-A (CsA) chronically and demonstrate an increased...

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Autores principales: Mineur, Yann S., Taylor, Seth R., Picciotto, Marina R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4037359/
https://ncbi.nlm.nih.gov/pubmed/24742621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.03.009
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